Kisspeptin
Kisspeptin (also known as Metastin or Kisspeptin-10) is a naturally occurring neuropeptide encoded by the KISS1 gene, acting through the KISS1R / GPR54 receptor. Extensively studied in preclinical and clinical research for its role in reproductive endocrinology, hypothalamic GnRH regulation, and HPG-axis signaling pathways. Lyophilized powder, ≥99% purity, third-party tested. For laboratory and research use only — not for human consumption.
| Peptide Family | Reproductive Neuropeptide |
|---|---|
| Research Application | Reproductive Research |
| Strength | 10 MG |
Kisspeptin — KISS1R Agonist Research Peptide
Kisspeptin is a naturally occurring neuropeptide encoded by the KISS1 gene and acts as the endogenous ligand for the KISS1R receptor (also known as GPR54). First identified in 1996 as a metastasis-suppressor gene product, Kisspeptin’s role in reproductive neuroendocrinology was established in 2003 when researchers demonstrated that loss-of-function mutations in KISS1R caused failure of pubertal development. Since then, Kisspeptin has emerged as a foundational reference compound in reproductive endocrinology research, with a published research base spanning both preclinical models and human clinical investigations.
This research-grade lyophilized Kisspeptin is supplied as Kisspeptin-10 (KP-10), the most extensively researched fragment of the native KISS1 protein.
Mechanism of Action
Kisspeptin has been investigated in published research for activity across several biological pathways, including:
- KISS1R / GPR54 receptor agonism — high-affinity binding to the kisspeptin receptor, a G-protein-coupled receptor expressed in hypothalamic GnRH neurons and reproductive tissues
- GnRH neuron activation — research on stimulation of gonadotropin-releasing hormone (GnRH) release from hypothalamic neurons
- HPG axis signaling — investigations into the upstream regulation of the hypothalamic-pituitary-gonadal axis, including LH and FSH release patterns
- Reproductive endocrinology research — studies on pubertal development, fertility pathway research, and reproductive cycle regulation in preclinical models
- Metastasis research — investigations into KISS1’s original-described role as a metastasis-suppressor gene in oncology research models
- Energy balance and metabolism research — research on Kisspeptin’s interaction with metabolic signaling pathways and leptin signaling
- Limbic system research — preclinical investigations into Kisspeptin’s role in mood and behavioral pathways
Kisspeptin occupies a unique position in reproductive endocrinology research as the upstream regulator of GnRH release — meaning it sits at the top of the HPG axis cascade. This makes Kisspeptin a foundational research tool for investigating reproductive function from a level upstream of where most other reproductive research compounds act.
Research Applications
Kisspeptin is widely used in research contexts including:
- KISS1R receptor pharmacology and signaling studies
- HPG axis and reproductive neuroendocrinology research
- Pubertal development and reproductive timing research models
- Fertility pathway and reproductive cycle research
- Comparative analysis alongside GnRH and other HPG-axis research compounds
- Energy balance and metabolic-reproductive crosstalk research
- Oncology research models involving KISS1 expression
Product Specifications
- Compound: Kisspeptin-10 (KP-10, KISS1 active fragment)
- Form: Lyophilized white powder
- Purity: ≥99% (verified by HPLC and mass spectrometry)
- Available sizes: 10mg
- Third-party tested: Certificate of Analysis available on request
Reconstitution & Storage
Lyophilized Kisspeptin should be stored at -20°C for long-term stability and protected from light. Once reconstituted with bacteriostatic water, the solution should be refrigerated at 2–8°C and used within the timeframe indicated on the product COA. Avoid repeated freeze-thaw cycles, as they can degrade peptide integrity.
Shipping & Handling
All orders are shipped with temperature-controlled packaging to preserve peptide integrity. Domestic orders typically arrive within 2–4 business days. Tracking is provided on every order.
Important Disclaimer
This product is sold strictly for laboratory research and in-vitro use only. It is not intended for human or animal consumption, diagnostic use, therapeutic use, fertility treatment, or any form of clinical or medical application. By purchasing, you confirm that you are a qualified researcher or affiliated with a licensed research institution and that this product will be handled in accordance with all applicable laws and safety standards.
Kisspeptin is an investigational research compound and is not approved by the FDA for human use. This product is not a substitute for any prescribed medication.
Domestic Shipping (Canada)
We ship Canada-wide using Canada Post Xpresspost with full tracking provided on every shipment.
Standard delivery: 2-5 business days nationwide
Free shipping on orders over $200 CAD
Discreet, unmarked packaging on all orders
Tracking number provided via email upon dispatch
Storage & Handling
Proper storage and handling are essential to maintaining peptide stability and ensuring the integrity of your research material.
Storage Recommendations
Lyophilized peptides should be stored at -20°C for long-term preservation. For short-term storage of up to 30 days, refrigeration between 2-8°C is acceptable. Reconstituted peptides should always be refrigerated and used within 30 days.
Avoid the following:
Direct sunlight or UV exposure Repeated freeze-thaw cycles Temperature fluctuations Storage at room temperature beyond brief handling periods
Reconstitution Best Practices
Allow vials to reach room temperature before opening to prevent condensation. Use bacteriostatic water as the diluent for most peptides, injecting slowly along the side of the vial. Gently swirl to dissolve — do not shake. Allow the solution to fully dissolve before drawing for research use.
Shelf Life
Lyophilized peptides maintain potency for up to 24 months when stored properly at -20°C. Reconstituted solutions should be used within 30 days for optimal research results.
Research Use Only
All products supplied by Kinetic Compounds are intended strictly for in-vitro laboratory research and development purposes.
Intended Use
These compounds are designed exclusively for qualified researchers and research institutions conducting laboratory studies. All products are research-grade and may not have been evaluated by the FDA for human use.
Prohibited Uses
Our products are NOT approved for:
Human consumption or administration Veterinary or animal use Diagnostic procedures Therapeutic applications Cosmetic application Resale for non-research purposes
Buyer Responsibility
By purchasing from Kinetic Compounds, you acknowledge and agree to the following:
You are a qualified researcher or represent a research institution All products will be used solely for in-vitro laboratory research You will handle products in accordance with applicable safety regulations You will not redistribute these compounds for human or animal consumption You assume full responsibility for the proper use and handling of these research materials
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