BPC-157
A 15-amino-acid synthetic peptide derived from a protective protein in human gastric juice, studied for tissue repair and GI protection.
Molecular Structure
Amino Acid Sequence
Molecular Formula
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What is BPC-157?
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide composed of 15 amino acids. It is a partial sequence derived from a larger protective protein naturally found in human gastric juice. First identified in the early 1990s, BPC-157 has been the subject of extensive preclinical research investigating its role in tissue repair, gastrointestinal protection, and angiogenesis.
The peptide is notable for its stability in gastric acid, which has made it a focus of studies exploring both injectable and oral research applications. BPC-157 does not occur naturally in this exact 15-amino-acid form and is produced synthetically for laboratory research purposes.
Mechanism of action
BPC-157’s mechanisms of action are still being characterized, but preclinical research has identified several pathways through which it appears to exert its effects:
– Upregulation of growth hormone receptor expression in tendon fibroblasts, which may enhance tissue healing responses
– Modulation of the nitric oxide (NO) system, influencing vascular tone and tissue perfusion
– Promotion of angiogenesis through increased VEGFR2 expression, supporting new blood vessel formation in damaged tissue
– Interaction with the dopaminergic and serotonergic systems in central nervous system studies
– Stabilization of gut barrier function and modulation of inflammatory cytokines in gastrointestinal models
These pathways are observed primarily in rodent models and in vitro systems. Human clinical data remains limited.
Research applications
BPC-157 has been studied across a wide range of preclinical research models, with the most active areas of investigation including:
– Musculoskeletal repair: Studies have examined BPC-157’s effects on tendon-to-bone healing, ligament reconstruction, and muscle crush injury recovery in rodent models.
– Gastrointestinal research: Extensive work has explored BPC-157’s protective effects in models of gastric ulcer, inflammatory bowel disease, and intestinal anastomosis healing.
– Vascular and angiogenic studies: Research has investigated BPC-157’s influence on blood vessel formation following ischemic injury.
– Neurological models: Preliminary studies have examined effects on traumatic brain injury, spinal cord injury, and neurotransmitter system modulation.
This compound is intended for laboratory research use only. It has not been approved for human therapeutic use by any regulatory agency.
Storage & reconstitution
Lyophilized (freeze-dried) BPC-157 is stable at room temperature for short-term shipping but should be stored long-term at -20°C (-4°F) protected from light. Under proper lyophilized storage conditions, the peptide remains stable for 24+ months.
Once reconstituted with bacteriostatic water, BPC-157 should be stored at 2–8°C (refrigerated) and used within 28 days. Avoid repeated freeze-thaw cycles, as these can degrade peptide integrity.
Always inspect the vial before use — the solution should be clear and free of particulates. Reconstituted peptide showing cloudiness, discoloration, or sediment should not be used in research.
For step-by-step reconstitution calculations, see our reconstitution calculator.
For laboratory research use only. The compound described on this page is intended exclusively for in vitro research and laboratory experimentation by qualified researchers and is not for human or veterinary use. It is not a drug, food, dietary supplement, or cosmetic, and has not been approved by the FDA, Health Canada, EMA, or any other regulatory authority for the diagnosis, treatment, cure, mitigation, or prevention of any disease or medical condition. The information provided on this page is for educational and reference purposes only and does not constitute medical advice. By accessing this content you confirm that you are a qualified researcher purchasing for legitimate laboratory purposes.
