SS-31
$65.00
SS-31 (also known as Elamipretide or Bendavia) is a synthetic mitochondrial-targeted tetrapeptide that selectively binds to cardiolipin in the inner mitochondrial membrane. Extensively studied in preclinical and clinical research for its role in mitochondrial function, ROS reduction, and cellular bioenergetics pathways. Lyophilized powder, ≥99% purity, third-party tested. For laboratory and research use only — not for human consumption.
| Peptide Family | Mitochondrial Peptide |
|---|---|
| Research Application | Mitochondrial Research |
| Strength | 10 MG |
SS-31 (Elamipretide) — Mitochondrial-Targeted Research Peptide
SS-31 is a synthetic mitochondrial-targeted tetrapeptide (D-Arg-2′,6′-dimethylTyr-Lys-Phe-NH2) developed at Cornell University by Dr. Hazel Szeto and Dr. Peter Schiller — the “SS” prefix refers to the names of the developers. Also known by the development codes Elamipretide and Bendavia, SS-31 belongs to the Szeto-Schiller (SS) peptide family of mitochondrial-targeted compounds and is one of the most extensively researched mitochondrial peptides in modern bioenergetics literature, with a clinical research base spanning multiple investigational trials.
Mechanism of Action
SS-31 has been investigated in published research for activity across several biological pathways, including:
- Cardiolipin binding — selective binding to cardiolipin, a phospholipid uniquely concentrated in the inner mitochondrial membrane
- Mitochondrial membrane stabilization — research on preservation of inner mitochondrial membrane structure and cristae architecture
- Electron transport chain efficiency — investigations into ETC complex assembly and electron flow through Complexes I–IV
- Reactive oxygen species (ROS) reduction — research on mitochondrial ROS generation and oxidative stress modulation
- ATP production — studies on cellular bioenergetics and ATP synthesis capacity in compromised mitochondria research models
- Mitochondrial permeability transition pore (mPTP) — research on mPTP opening and mitochondrial-driven apoptosis pathways
- Cytochrome c stabilization — investigations into cardiolipin-cytochrome c interactions in the electron transport chain
SS-31 is distinguished in mitochondrial research literature by its selective targeting mechanism — the peptide accumulates in the inner mitochondrial membrane through its affinity for cardiolipin, independently of mitochondrial membrane potential. This passive, potential-independent targeting allows SS-31 to localize to mitochondria even in cells where mitochondrial function is already compromised, which is a defining feature in research models of mitochondrial dysfunction.
Research Applications
SS-31 is widely used in research contexts including:
- Mitochondrial dysfunction and bioenergetics research models
- Cardiovascular research, particularly ischemia-reperfusion injury models
- Renal and kidney function research
- Heart failure and cardiac mitochondrial research
- Aging and mitochondrial decline research
- Neurodegenerative research models involving mitochondrial pathology
- Skeletal muscle and exercise physiology research
- Comparative analysis alongside other mitochondrial-active research compounds such as MOTS-c, NAD+, and Coenzyme Q10 analogs
- Ophthalmologic research, including dry age-related macular degeneration models
Product Specifications
- Compound: SS-31 (Elamipretide, Bendavia)
- Sequence: D-Arg-Dmt-Lys-Phe-NH2
- Form: Lyophilized white powder
- Purity: ≥99% (verified by HPLC and mass spectrometry)
- Available sizes: 10mg
- Third-party tested: Certificate of Analysis available on request
Reconstitution & Storage
Lyophilized SS-31 should be stored at -20°C for long-term stability and protected from light. Once reconstituted with bacteriostatic water, the solution should be refrigerated at 2–8°C and used within the timeframe indicated on the product COA. Avoid repeated freeze-thaw cycles, as they can degrade peptide integrity.
Shipping & Handling
All orders are shipped with temperature-controlled packaging to preserve peptide integrity. Domestic orders typically arrive within 2–4 business days. Tracking is provided on every order.
Important Disclaimer
This product is sold strictly for laboratory research and in-vitro use only. It is not intended for human or animal consumption, diagnostic use, therapeutic use, or any form of clinical application. By purchasing, you confirm that you are a qualified researcher or affiliated with a licensed research institution and that this product will be handled in accordance with all applicable laws and safety standards.
SS-31 (Elamipretide) is an investigational compound that has been studied in human clinical trials but is not currently approved by the FDA for human use. This product is not a substitute for any prescribed medication.
Domestic Shipping (Canada)
We ship Canada-wide using Canada Post Xpresspost with full tracking provided on every shipment.
Standard delivery: 2-5 business days nationwide
Free shipping on orders over $200 CAD
Discreet, unmarked packaging on all orders
Tracking number provided via email upon dispatch
Storage & Handling
Proper storage and handling are essential to maintaining peptide stability and ensuring the integrity of your research material.
Storage Recommendations
Lyophilized peptides should be stored at -20°C for long-term preservation. For short-term storage of up to 30 days, refrigeration between 2-8°C is acceptable. Reconstituted peptides should always be refrigerated and used within 30 days.
Avoid the following:
Direct sunlight or UV exposure Repeated freeze-thaw cycles Temperature fluctuations Storage at room temperature beyond brief handling periods
Reconstitution Best Practices
Allow vials to reach room temperature before opening to prevent condensation. Use bacteriostatic water as the diluent for most peptides, injecting slowly along the side of the vial. Gently swirl to dissolve — do not shake. Allow the solution to fully dissolve before drawing for research use.
Shelf Life
Lyophilized peptides maintain potency for up to 24 months when stored properly at -20°C. Reconstituted solutions should be used within 30 days for optimal research results.
Research Use Only
All products supplied by Kinetic Compounds are intended strictly for in-vitro laboratory research and development purposes.
Intended Use
These compounds are designed exclusively for qualified researchers and research institutions conducting laboratory studies. All products are research-grade and may not have been evaluated by the FDA for human use.
Prohibited Uses
Our products are NOT approved for:
Human consumption or administration Veterinary or animal use Diagnostic procedures Therapeutic applications Cosmetic application Resale for non-research purposes
Buyer Responsibility
By purchasing from Kinetic Compounds, you acknowledge and agree to the following:
You are a qualified researcher or represent a research institution All products will be used solely for in-vitro laboratory research You will handle products in accordance with applicable safety regulations You will not redistribute these compounds for human or animal consumption You assume full responsibility for the proper use and handling of these research materials
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