MOTS-c
Price range: $45.00 through $130.00
MOTS-c is a synthetic 16-amino-acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S rRNA region. Extensively studied in preclinical research for its role in metabolic homeostasis, AMPK signaling, and mitochondrial function pathways. Lyophilized powder, ≥99% purity, third-party tested. For laboratory and research use only — not for human consumption.
| Peptide Family | Mitochondrial Peptide |
|---|---|
| Research Application | Metabolic Research, Mitochondrial Research |
| Strength | 10 MG, 50 MG |
MOTS-c — Mitochondrial-Derived Peptide Research Compound
MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA-c) is a synthetic 16-amino-acid peptide encoded within a small open reading frame in the mitochondrial 12S rRNA gene. First identified in 2015, MOTS-c is one of a small group of mitochondrial-derived peptides (MDPs) — a relatively new class of regulatory peptides encoded by mitochondrial DNA rather than nuclear DNA. It has rapidly become one of the most extensively researched peptides in modern metabolic and longevity science literature.
Mechanism of Action
MOTS-c has been investigated in published research for activity across several biological pathways, including:
- AMPK pathway activation — research on AMP-activated protein kinase signaling, a central regulator of cellular energy homeostasis
- Mitochondrial function — investigations into mitochondrial biogenesis, oxidative phosphorylation, and metabolic flexibility
- Glucose homeostasis — research on insulin sensitivity and glucose uptake in preclinical models
- Folate cycle and one-carbon metabolism — studies on MOTS-c’s interaction with folate-dependent metabolic pathways
- Nuclear translocation — research on MOTS-c’s documented movement from mitochondria to the cell nucleus under metabolic stress, where it influences gene expression
- Exercise-mimetic pathways — investigations into MOTS-c’s role in metabolic adaptations associated with physical activity in preclinical models
MOTS-c is unusual in research literature because it represents a newer concept in cellular biology — that mitochondria encode and release their own regulatory peptides that signal to the rest of the cell. This positions MOTS-c as both a research compound and a foundational tool for investigating the broader category of mitochondrial-derived signaling.
Research Applications
MOTS-c is widely used in research contexts including:
- Mitochondrial biology and bioenergetics studies
- AMPK signaling and cellular energy homeostasis research
- Metabolic syndrome and insulin sensitivity research models
- Glucose metabolism and adipose tissue research
- Longevity and cellular aging research
- Exercise physiology and metabolic adaptation research models
- Comparative studies alongside other mitochondrial-derived peptides such as Humanin and SHLPs
Product Specifications
- Compound: MOTS-c (Mitochondrial-Derived Peptide)
- Form: Lyophilized white powder
- Purity: ≥99% (verified by HPLC and mass spectrometry)
- Available sizes: 10mg/50mg
- Third-party tested: Certificate of Analysis available on request
Reconstitution & Storage
Lyophilized MOTS-c should be stored at -20°C for long-term stability and protected from light. Once reconstituted with bacteriostatic water, the solution should be refrigerated at 2–8°C and used within the timeframe indicated on the product COA. Avoid repeated freeze-thaw cycles, as they can degrade peptide integrity.
Shipping & Handling
All orders are shipped with temperature-controlled packaging to preserve peptide integrity. Domestic orders typically arrive within 2–4 business days. Tracking is provided on every order.
Important Disclaimer
This product is sold strictly for laboratory research and in-vitro use only. It is not intended for human or animal consumption, diagnostic use, therapeutic use, or any form of clinical application. By purchasing, you confirm that you are a qualified researcher or affiliated with a licensed research institution and that this product will be handled in accordance with all applicable laws and safety standards.
MOTS-c is not approved by the FDA for human use, and this product is not a substitute for any prescribed medication.
Domestic Shipping (Canada)
We ship Canada-wide using Canada Post Xpresspost with full tracking provided on every shipment.
Standard delivery: 2-5 business days nationwide
Free shipping on orders over $200 CAD
Discreet, unmarked packaging on all orders
Tracking number provided via email upon dispatch
Storage & Handling
Proper storage and handling are essential to maintaining peptide stability and ensuring the integrity of your research material.
Storage Recommendations
Lyophilized peptides should be stored at -20°C for long-term preservation. For short-term storage of up to 30 days, refrigeration between 2-8°C is acceptable. Reconstituted peptides should always be refrigerated and used within 30 days.
Avoid the following:
Direct sunlight or UV exposure Repeated freeze-thaw cycles Temperature fluctuations Storage at room temperature beyond brief handling periods
Reconstitution Best Practices
Allow vials to reach room temperature before opening to prevent condensation. Use bacteriostatic water as the diluent for most peptides, injecting slowly along the side of the vial. Gently swirl to dissolve — do not shake. Allow the solution to fully dissolve before drawing for research use.
Shelf Life
Lyophilized peptides maintain potency for up to 24 months when stored properly at -20°C. Reconstituted solutions should be used within 30 days for optimal research results.
Research Use Only
All products supplied by Kinetic Compounds are intended strictly for in-vitro laboratory research and development purposes.
Intended Use
These compounds are designed exclusively for qualified researchers and research institutions conducting laboratory studies. All products are research-grade and may not have been evaluated by the FDA for human use.
Prohibited Uses
Our products are NOT approved for:
Human consumption or administration Veterinary or animal use Diagnostic procedures Therapeutic applications Cosmetic application Resale for non-research purposes
Buyer Responsibility
By purchasing from Kinetic Compounds, you acknowledge and agree to the following:
You are a qualified researcher or represent a research institution All products will be used solely for in-vitro laboratory research You will handle products in accordance with applicable safety regulations You will not redistribute these compounds for human or animal consumption You assume full responsibility for the proper use and handling of these research materials
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