Melatonin
$20.00
Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring indoleamine synthesized primarily by the pineal gland from tryptophan via serotonin. Extensively studied in preclinical research for its role in circadian regulation, antioxidant pathways, and neuroendocrine signaling. Lyophilized powder, ≥99% purity, third-party tested. For laboratory and research use only — not for human consumption.
| Peptide Family | Neuropeptide |
|---|---|
| Research Application | Longevity Research, Sleep Research |
| Strength | 10 MG |
Melatonin — Indoleamine Research Compound
Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring indoleamine synthesized primarily by the pineal gland from the amino acid tryptophan via serotonin. First isolated and characterized in 1958 by Aaron Lerner and colleagues at Yale, Melatonin is one of the most extensively researched signaling molecules in modern chronobiology, neuroendocrinology, and antioxidant research literature, with a published research base spanning more than six decades.
This research-grade lyophilized Melatonin powder is supplied for laboratory research applications, distinct from the consumer dietary supplement forms widely available in over-the-counter markets.
Mechanism of Action
Melatonin has been investigated in published research for activity across several biological pathways, including:
- MT1 and MT2 receptor agonism — binding to the two primary melatonin receptors, both G-protein-coupled receptors widely expressed across the central nervous system and peripheral tissues
- Circadian regulation — research on suprachiasmatic nucleus function and biological-clock entrainment pathways
- Antioxidant activity — direct free radical scavenging and indirect upregulation of endogenous antioxidant enzymes including SOD, catalase, and glutathione peroxidase
- Mitochondrial research — investigations into Melatonin’s documented activity at mitochondrial membranes and its influence on oxidative phosphorylation
- Neuroendocrine pathway research — studies on HPA axis interaction, prolactin secretion, and reproductive hormone signaling
- Immune modulation — research on cytokine signaling and lymphocyte function in preclinical models
- Cellular signaling — investigations into MT1/MT2-independent pathways including direct nuclear receptor interaction (RORα/RZR) and calmodulin binding
Melatonin is unusual in research literature in that it functions as both a hormone (through receptor-mediated signaling) and a direct antioxidant (through chemical free radical scavenging), making it a uniquely multi-modal research compound across endocrine, chronobiology, and oxidative stress research disciplines.
Research Applications
Melatonin is widely used in research contexts including:
- Circadian rhythm and chronobiology research
- Sleep architecture and EEG research models
- Antioxidant and oxidative stress pathway studies
- Neuroprotection and neurodegenerative research models
- Mitochondrial function and bioenergetics research
- Reproductive endocrinology research
- Immune modulation and inflammatory pathway studies
- Comparative analysis alongside other CNS-active research compounds including DSIP
- Cellular aging and senescence research
Product Specifications
- Compound: Melatonin (N-acetyl-5-methoxytryptamine)
- Form: Lyophilized powder, research grade
- Purity: ≥99% (verified by HPLC and mass spectrometry)
- Available sizes: 10mg
- Third-party tested: Certificate of Analysis available on request
Reconstitution & Storage
Lyophilized Melatonin should be stored at -20°C for long-term stability and protected from light. Melatonin is particularly photosensitive — exposure to light causes rapid degradation, even in lyophilized form, so light-protected storage is essential. Once reconstituted, the solution should be refrigerated at 2–8°C, stored in opaque or amber containers to protect from light, and used within the timeframe indicated on the product COA. Avoid repeated freeze-thaw cycles, as they can degrade compound integrity.
Note: Melatonin has limited solubility in pure water. For research applications requiring full dissolution, researchers commonly use small amounts of ethanol or DMSO as a co-solvent according to specific research protocols.
Shipping & Handling
All orders are shipped with light-protective packaging to preserve compound integrity. Domestic orders typically arrive within 2–4 business days. Tracking is provided on every order.
Important Disclaimer
This product is sold strictly for laboratory research and in-vitro use only. It is not intended for human or animal consumption, diagnostic use, therapeutic use, sleep aid, dietary supplement use, or any form of clinical, medical, or personal application. By purchasing, you confirm that you are a qualified researcher or affiliated with a licensed research institution and that this product will be handled in accordance with all applicable laws and safety standards.
Melatonin is available as an over-the-counter dietary supplement in some jurisdictions, including the United States, where it is regulated under different rules than this research-grade compound. This product is supplied for laboratory research purposes only and is not a dietary supplement.
Domestic Shipping (Canada)
We ship Canada-wide using Canada Post Xpresspost with full tracking provided on every shipment.
Standard delivery: 2-5 business days nationwide
Free shipping on orders over $200 CAD
Discreet, unmarked packaging on all orders
Tracking number provided via email upon dispatch
Storage & Handling
Proper storage and handling are essential to maintaining peptide stability and ensuring the integrity of your research material.
Storage Recommendations
Lyophilized peptides should be stored at -20°C for long-term preservation. For short-term storage of up to 30 days, refrigeration between 2-8°C is acceptable. Reconstituted peptides should always be refrigerated and used within 30 days.
Avoid the following:
Direct sunlight or UV exposure Repeated freeze-thaw cycles Temperature fluctuations Storage at room temperature beyond brief handling periods
Reconstitution Best Practices
Allow vials to reach room temperature before opening to prevent condensation. Use bacteriostatic water as the diluent for most peptides, injecting slowly along the side of the vial. Gently swirl to dissolve — do not shake. Allow the solution to fully dissolve before drawing for research use.
Shelf Life
Lyophilized peptides maintain potency for up to 24 months when stored properly at -20°C. Reconstituted solutions should be used within 30 days for optimal research results.
Research Use Only
All products supplied by Kinetic Compounds are intended strictly for in-vitro laboratory research and development purposes.
Intended Use
These compounds are designed exclusively for qualified researchers and research institutions conducting laboratory studies. All products are research-grade and may not have been evaluated by the FDA for human use.
Prohibited Uses
Our products are NOT approved for:
Human consumption or administration Veterinary or animal use Diagnostic procedures Therapeutic applications Cosmetic application Resale for non-research purposes
Buyer Responsibility
By purchasing from Kinetic Compounds, you acknowledge and agree to the following:
You are a qualified researcher or represent a research institution All products will be used solely for in-vitro laboratory research You will handle products in accordance with applicable safety regulations You will not redistribute these compounds for human or animal consumption You assume full responsibility for the proper use and handling of these research materials
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