5-Amino-1MQ
$47.00
5-Amino-1MQ (5-amino-1-methylquinolinium) is a synthetic small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular methylation and metabolic pathway regulation. Studied in preclinical research for its role in NNMT inhibition, adipose tissue research, and cellular NAD+ metabolism pathways. Crystalline powder, ≥98% purity, third-party tested. For laboratory and research use only — not for human consumption.
| Peptide Family | Mitochondrial Peptide |
|---|---|
| Research Application | Metabolic Research |
| Strength | 10 MG |
5-Amino-1MQ — NNMT Inhibitor Research Compound
5-Amino-1MQ (5-amino-1-methylquinolinium) is a synthetic small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that catalyzes the methylation of nicotinamide using S-adenosyl methionine (SAM) as a methyl donor. NNMT is increasingly recognized in research literature as a regulator of cellular methylation balance, NAD+ metabolism, and adipose tissue metabolic function — and 5-Amino-1MQ has emerged as the most extensively studied small-molecule NNMT inhibitor research tool currently available.
Mechanism of Action
5-Amino-1MQ has been investigated in published research for activity across several biological pathways, including:
- NNMT enzyme inhibition — direct competitive inhibition of nicotinamide N-methyltransferase, the enzyme responsible for the methylation of nicotinamide to 1-methylnicotinamide (1-MNA)
- Cellular methylation balance — research on the influence of NNMT inhibition on the methyl donor pool, particularly S-adenosyl methionine (SAM) and S-adenosyl homocysteine (SAH) ratios
- NAD+ salvage pathway research — investigations into how NNMT inhibition affects nicotinamide availability for NAD+ resynthesis via the salvage pathway
- Adipose tissue research — preclinical research on NNMT expression in white adipose tissue and its relationship to adipocyte size, energy expenditure, and metabolic flexibility
- Sirtuin pathway research — investigations into downstream effects on sirtuin (SIRT1-7) activity through changes in cellular NAD+ availability
- Obesity and metabolic syndrome research models — studies on NNMT-mediated metabolic regulation in preclinical animal models
- Aging research — research on NNMT expression patterns in aging tissues and the effects of NNMT inhibition in cellular senescence models
5-Amino-1MQ is distinguished in research literature as a research tool for investigating NNMT-mediated regulation of cellular methylation and metabolic pathways. The compound’s mechanism — inhibition of nicotinamide methylation — represents a relatively novel approach to indirect modulation of NAD+ availability, complementing direct NAD+ precursor research approaches such as NMN and NR.
Research Applications
5-Amino-1MQ is widely used in research contexts including:
- NNMT enzyme inhibition and selectivity studies
- Cellular methylation and one-carbon metabolism research
- NAD+ salvage pathway and nicotinamide metabolism research
- Adipose tissue and adipocyte biology research models
- Metabolic syndrome and obesity research models
- Cellular senescence and aging research
- Comparative analysis alongside other metabolic research compounds such as MOTS-c, NAD+, and SLU-PP-332
Product Specifications
- Compound: 5-Amino-1MQ (5-amino-1-methylquinolinium)
- Form: Crystalline powder
- Purity: ≥98% (verified by HPLC and mass spectrometry)
- Available sizes: 10mg
- Third-party tested: Certificate of Analysis available on request
Reconstitution & Storage
5-Amino-1MQ should be stored at -20°C for long-term stability and protected from light and moisture. As a small-molecule research chemical, 5-Amino-1MQ has limited solubility in water and is typically dissolved in DMSO (dimethyl sulfoxide) or ethanol for laboratory research applications. Working solutions should be prepared according to the specific research protocol and stored at conditions appropriate to the solvent system used.
Researchers should consult published literature for recommended solubility parameters and handling procedures specific to their research model.
Shipping & Handling
All orders are shipped with appropriate packaging to preserve compound integrity. Domestic orders typically arrive within 2–4 business days. Tracking is provided on every order.
Important Disclaimer
This product is sold strictly for laboratory research and in-vitro use only. It is not intended for human or animal consumption, diagnostic use, therapeutic use, or any form of clinical application. By purchasing, you confirm that you are a qualified researcher or affiliated with a licensed research institution and that this product will be handled in accordance with all applicable laws and safety standards.
5-Amino-1MQ has not undergone human clinical trials and is not approved by the FDA for any use. Published research on this compound is limited to preclinical animal and cell-based models. This product is not a substitute for any prescribed medication.
Domestic Shipping (Canada)
We ship Canada-wide using Canada Post Xpresspost with full tracking provided on every shipment.
Standard delivery: 2-5 business days nationwide
Free shipping on orders over $200 CAD
Discreet, unmarked packaging on all orders
Tracking number provided via email upon dispatch
Storage & Handling
Proper storage and handling are essential to maintaining peptide stability and ensuring the integrity of your research material.
Storage Recommendations
Lyophilized peptides should be stored at -20°C for long-term preservation. For short-term storage of up to 30 days, refrigeration between 2-8°C is acceptable. Reconstituted peptides should always be refrigerated and used within 30 days.
Avoid the following:
Direct sunlight or UV exposure Repeated freeze-thaw cycles Temperature fluctuations Storage at room temperature beyond brief handling periods
Reconstitution Best Practices
Allow vials to reach room temperature before opening to prevent condensation. Use bacteriostatic water as the diluent for most peptides, injecting slowly along the side of the vial. Gently swirl to dissolve — do not shake. Allow the solution to fully dissolve before drawing for research use.
Shelf Life
Lyophilized peptides maintain potency for up to 24 months when stored properly at -20°C. Reconstituted solutions should be used within 30 days for optimal research results.
Research Use Only
All products supplied by Kinetic Compounds are intended strictly for in-vitro laboratory research and development purposes.
Intended Use
These compounds are designed exclusively for qualified researchers and research institutions conducting laboratory studies. All products are research-grade and may not have been evaluated by the FDA for human use.
Prohibited Uses
Our products are NOT approved for:
Human consumption or administration Veterinary or animal use Diagnostic procedures Therapeutic applications Cosmetic application Resale for non-research purposes
Buyer Responsibility
By purchasing from Kinetic Compounds, you acknowledge and agree to the following:
You are a qualified researcher or represent a research institution All products will be used solely for in-vitro laboratory research You will handle products in accordance with applicable safety regulations You will not redistribute these compounds for human or animal consumption You assume full responsibility for the proper use and handling of these research materials
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